| 品牌 | 其他品牌 | 適用領域 | 科研 |
|---|---|---|---|
| 產地 | 進口 | 加工定制 | 是 |
廣州鴻程生物有限公司一家專注于生命科學的科技企業，由在國內科研試劑領域有著豐富從業經驗的技術團隊和管理團隊組建而成，專營進口生物試劑，科學儀器，實驗消耗品等。公司將不斷把上優質的產品引入國內市場，滿足客戶的需求，公司也將緊跟生命科學的發展，為廣大科研工作者探索生命科學的奧秘奉獻綿薄之力.專門從事以抗*Beckman A63881的磁珠 現貨，moltox 11-101.5等現貨，transgenomic 706020/706025現貨
BioLog Life Science 廣州鴻程代理
Biolog 是一家總部位于德國的創新型和科學型企業，專注于信號轉導研究工具。
這家通過 ISO 9001 認證的公司專注于核苷酸化學，特別強調基于環核苷酸的各種蛋白激酶、磷酸二酯酶和離子通道等調節劑。
許多稀有的高純度環狀 AMP 和 GMP 激動劑和拮抗劑已被開發出來，它們在膜通透性、受體特異性和激酶同工酶選擇性方面不同或帶有熒光標記。
對于環狀核苷酸結合蛋白的親和層析，也可以使用具有 PDE 穩定配體結構的凝膠。
定制合成和定制純化，特別是在單磷酸、二磷酸和三磷酸以及熒光標記領域是該公司的其他主要業務。
在 Biolog，對環狀核苷酸反應受體的新型特異性調節劑進行了長期研究，這已經導致了幾種普遍接受的信號轉導研究工具，例如 PKA 和 PKG 抑制劑以及 Epac 特異性激動劑。
該公司還與其他研究小組進行科學合作，主要是在受體定位研究和通過核苷酸類似物開發新型酶調節劑（點擊此處查看參考文獻列表）。
由于提供的大多數產品都是在自己的實驗室合成的，因此在核苷酸化學和相應的科學領域有很強的背景。
Technical Information about c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p]
Update: March 21, 2022
Formula | CAS No. | Molecular Weight | UV | BIOLOG Cat. No. |
C59 H74 N14O21 P2S2 (free acid) | [pending] | 1441.4 (free acid) |
| C 270 |
Name: Cyclic (3'- O- (6- [sulfo-cyanine5]aminohexylcarbamoyl)guanosine- (2' ?> 5')- monophosphate- adenosine- (3' ?> 5')- monophosphate) sodium salt
Description: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is a fluorescently labelled version of the metazoan cyclic dinucleotide second messenger c[G(2',5')pA(3',5')p] (aka cGAMP(2'-5') or 2'3'-cGAMP, Cat. No. C 161) in which the sulfo-Cyanine 5 fluorophore has been attached to the free ribose-3' position of the cyclic structure via an aminohexylcarbamoyl spacer.
Properties: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is fluorescent with 
exc 646 nm and em 662 nm. The parent compound c[G(2',5')pA(3',5')p] (Cat. No. C 161) was found to be the metazoan second messenger produced by the mammalian innate immune DNA sensor cGAMP synthase (cGAS).
Specification: Crystallized or lyophilized sodium salt. Please keep in mind that equal concentrations of the compound may look different in volume due to sensitivity of the lyophilized form to humidity. The compound can even contract to small volume droplets. Normally the product is located in the conical bottom of the tube. Micromolar quantities are determined by UV/VIS at max .
Purity: Typical analysis is better than 95% (HPLC / UV 258 nm / VIS 646 nm). The product is not sterile and has not been tested for endotoxins.
Solubility: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is soluble in water (≥ 1 mM, limits have not been determined). Please rinse tube walls carefully and preferably use ultrasonic or vortex to achieve total and uniform mixing. When opening the tube please make sure that no substance is lost within the cap.
Stability and Storage: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is chemically relatively stable. Nevertheless, the compound should be protected from light and stored in the freezer (- 20° Celsius necessary, - 80° recommended), for longer storage periods preferably in freeze-dried form.
Toxicity and Safety: Please keep in mind, that the in vivo properties of this compound are not sufficiently characterized up to now. Avoid skin contact or ingestion and allow only trained personnel to handle the product. Our products are designed, developed and sold for research purposes only! They are intended for in vitro and nonhuman in vivo laboratory applications. Any other use requires approval of health authorities.
Not for drug, household or related uses!
Selected References for c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p]: c[3'-[sCya5]-AHC-G(2',5')pA(3',5')p] is a new product and there are currently no corresponding references available.
Selected References for the Parent Compound c[G(2',5')pA(3',5')p]:
Bridgeman, A.; Maelfait, J.; Davenne, T.; Partridge T.; Peng, Y.; Mayer, A.; Dong, T.; Kaever, V.; Borrow, P.; Rehwinkel J., Science, 349, 1228 - 1232 (2015): "Viruses Transfer the Antiviral Second Messenger cGAMP Between Cells"
Lolicato, M.;Bucchi, A.;Arrigoni, C.;Zucca, S.;Nardini, M.;Schroeder, I.;Simmons, K.;Aquila, M.;DiFrancesco, D.;Bolognesi, M.; Schwede, F.; Kashin, D.;Fishwick, C.W.;Johnson, A.P.;Thiel, G.;Moroni, A., Nat. Chem. Biol., 10, 457 - 462 (2014): "Cyclic Dinucleotides bind the C-linker of HCN4 to Control Channel cAMP Responsiveness"
Konno, H.; Konno, K.; Barber, G.N., Cell, 155 688 - 698 (2013): "Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling"
Ablasser, A.; Schmid-Burgk, J.L.; Hemmerling, I.; Horvath, G.L.; Schmidt, T.; Latz, E.; Hornung, V., Nature, 503, 530 - 534 (2013): "Cell Intrinsic Immunity Spreads to Bystander Cells via the Intercellular Transfer of cGAMP"
Li, X.D.; Wu, J.; Gao, D.; Wang, H.; Sun, L.; Chen, Z.J., Science, 341, 1390 - 1394 (2013): "Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects"
Gao, D.; Wu, J.; Wu, Y.T.; Du, F.; Aroh, C.; Yan, N.; Sun, L.; Chen, Z.J., Science, 341, 903 - 906 (2013): "Cyclic GMP-AMP Synthase is an Innate Immune Sensor of HIV and Other Retroviruses"
Gao, P.; Ascano, M.; Wu, Y.; Barchet, W.; Gaffney, B.L.; Zillinger, T.; Serganov, A.A.; Liu, Y.; Jones R.A.; Hartmann, G.; Tuschl, T.; Patel, D.J., Cell, 153, 1094 - 1107 (2013): "Cyclic [G(2',5')pA(3',5')p] Is the Metazoan Second Messenger Produced by DNA- Activated Cyclic GMP-AMP Synthase"
Ablasser, A.; Goldeck, M.; Cavlar, T.; Deimling T.; Witte, G.; R?hl, I.; Hopfner, K.-P.; Ludwig, J.; Hornung, V., Nature, 498, 380 - 384 (2013): "cGAS Produces a 2'-5'-linked Cyclic Dinucleotide Second Messenger that Activates STING"
Zhang, X.; Shi, H.; Wu, J.; Zhang, X.; Sun, L.; Chen, C.; Chen, Z .J., Mol. Cell, 51, 226 - 235 (2013): "Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING"
Diner, E.J.; Burdette, D.L.; Wilson, S.C.; Monroe, K.M.; Kellenberger, C.A.; Hyodo, M.; Hayakawa, Y.; Hammond, M.C.; Vance, R.E., Cell Rep., 3 1355 - 1361 (2013): "The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING"
Wu, J.;Sun, L.;Chen, X.;Du, F.;Shi, H.;Chen, C.;Chen, Z.J.,Science, 339, 826 - 830 (2013): "Cyclic GMP-AMP is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA"
Sun, L.;Wu, J.;Du, F.;Chen, X.;Chen, Z.J.,Science, 339, 786 - 791 (2013): "Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway"
